The Philadelphia Eagles have lost quarterback Jalen Hurts to concussion then had their 10-match winning streak snapped in a 36-33 loss to the Washington Commanders on a tough day for the NFC East leaders.

Rookie quarterback Jayden Daniels threw five touchdown passes while running at will in his latest masterful performance for the Commanders as they rallied to secure the home victory on Sunday.

Daniels' heroics culminated with a 57-yard touchdown drive in the final 1:58, finding Jamison Crowder in the end zone with 6 seconds left.

The Commanders (10-5) trailed by 14 going into the fourth quarter but are now on the verge of making the playoffs after handing Philadelphia (12-3) their first loss since September 29.

The Eagles played without Hurts for the vast majority of the game and failed to clinch the division and one of the conference's top two seeds.

Hurts' status is a question that will linger into their final two games of the regular season as the Super Bowl contenders eye a long playoff run.

Elsewhere, Jared Goff threw for 336 yards and three touchdowns as Detroit remained on top of the NFC with their franchise-record 13th win, triumphing 34-17 over hosts Chicago.

Matthew Stafford threw a go-ahead 11-yard touchdown pass to Tyler Higbee early in the fourth quarter after a turnover by Aaron Rodgers as the visiting Los Angeles Rams beat the New York Jets 19-9 for their fourth consecutive victory.

The Rams (9-6), who have won five of six, maintained their spot atop the NFC West standings with the victory.

In Cincinnati, Joe Burrow threw three touchdown passes as the Bengals (7-8) kept their slim playoff hopes alive with a victory 24-6 over Cleveland.

In Seattle, Sam Darnold connected with a well-covered Justin Jefferson with 3:51 left for his third TD pass of the game as Minnesota outlasted the Seahawks 27-24 to keep pace with Detroit for the top spot in the NFC.

James Cook scored two touchdowns and Buffalo's defence forced three second-half turnovers as the AFC East champion Bills overcame a 14-0 deficit to pull out a win over New England.

In Atlanta, Michael Penix Jr. won his debut as the Falcons' starting quarterback as his team (8-7) bolstered their playoff hopes by handing the New York Giants their franchise-record 10th straight loss, 34-7.

In Charlotte, Chuba Hubbard ran for a 21-yard touchdown in overtime as Carolina eliminated Arizona from playoff contention with a 36-30 victory.

In Miami, Tua Tagovailoa threw for 215 yards and a touchdown and Jason Sanders nailed five field goals for Miami who kept their playoff chances alive by beating eliminated San Francisco 29-17.

Jonathan Taylor rushed for 218 yards and scored three times including runs of 65 and 70 yards to lead hosts Indianapolis past Tennessee 38-30.

In Las Vegas, Aidan O'Connell returned from an injury and passed for 257 yards to help the Las Vegas Raiders end their 10-game losing streak with a 19-14 victory over the Jacksonville Jaguars.

The victory, however, means the Raiders (3-12) moved ahead of the league-worst New York Giants (2-13). The team with the worst record is in line for the top pick in next year's draft.